Which statement is true regarding animal protocol modifications?

The statement that every change needs a review depending on its significance is correct because animal protocol modifications are subject to the criteria set by the IACUC (Institutional Animal Care and Use Committee). Changes made to an existing protocol—whether they are considered minor or major—must be reviewed to ensure that they adhere to ethical standards, regulations, and the welfare of the animals involved.

This means that even seemingly minor alterations may have implications that require evaluation by the IACUC. The determination of the significance of each change helps maintain high standards of animal care and ensures the continuation of compliance with regulations. By evaluating every alteration appropriately, the IACUC can make informed decisions that protect animal welfare while still allowing for necessary adaptations to scientific protocols.

In contrast, the other statements misrepresent the IACUC's policies. Minor changes cannot always be made spontaneously; they may still require review. Only major changes do not solely warrant attention, as both major and minor modifications are significant in their own rights. Additionally, changes are not reviewed only once a year; they need to be assessed as they arise to ensure ongoing compliance with ethical standards.