What action must be taken if an animal experiences unexpected adverse effects during a research study?

When an animal experiences unexpected adverse effects during a research study, it is crucial to report these effects to the Institutional Animal Care and Use Committee (IACUC) immediately. This is essential for several reasons. Firstly, IACUC is responsible for the oversight of animal welfare in research, and timely reporting ensures that any potential pain or distress the animal is experiencing is addressed promptly. It allows the committee to assess the situation and determine if further investigation, alterations in the study design, or immediate intervention is necessary to protect the animal's welfare.

Additionally, immediate reporting serves as a protective measure to maintain compliance with ethical standards and regulations governing animal research. This action not only safeguards the health of the affected animal but also contributes to the overall integrity of the research project and the institution.

Other options, such as disregarding the effect, informing only animal care staff, or waiting until the study is completed, would not adequately address the ethical and welfare concerns that arise in such situations. These actions could lead to further suffering for the animal and suggest a failure to prioritize animal welfare, which is a fundamental principle of responsible research.