True or False: All significant changes to an animal use protocol need IACUC approval.

The statement that all significant changes to an animal use protocol need IACUC approval is accurate. The Institutional Animal Care and Use Committee (IACUC) is responsible for ensuring that all research involving animals is conducted ethically and in accordance with regulations. When a research protocol is modified, even if the changes may seem minor, they can impact animal welfare, research outcomes, or compliance with federal regulations. Therefore, significant changes must be reviewed and approved by the IACUC before they are implemented to ensure that they meet ethical standards and regulatory requirements. This comprehensive review process helps to safeguard the welfare of the animals involved in research and the integrity of the scientific process.