Methods for substance administration in rats and mice are outlined in which document?

The Guide, specifically titled "The Guide for the Care and Use of Laboratory Animals," is the comprehensive document recognized by the National Institutes of Health and other organizations to provide guidance on the proper care and use of laboratory animals. This includes detailed descriptions of methods for substance administration in rats, mice, and other species, emphasizing humane treatment and scientific rigor. The Guide is widely regarded as the key resource for institutions working with laboratory animals, outlining best practices and regulatory compliance, thus serving as a critical reference for researchers in designing their studies.

While other documents like The Manual of Laboratory Animal Science, the Animal Welfare Act, and the Research Ethics Code address various aspects of animal care and welfare, they do not provide the same level of detail regarding methodologies for substance administration as The Guide does. This specificity makes The Guide the primary and most authoritative source for best practices in this area.