Can changes in the procedure that increase pain be made without IACUC approval?

Changes in procedures that increase pain to animals must always receive IACUC approval before implementation. The IACUC (Institutional Animal Care and Use Committee) is responsible for ensuring that animal research adheres to ethical and legal standards, prioritizing animal welfare. Any modification that could increase the level of pain, distress, or discomfort experienced by the animals falls under scrutiny, as such changes can alter the risk-benefit assessment initially conducted by the committee.

The principle of the three R's — Replacement, Reduction, and Refinement — underscores the importance of minimizing pain and distress in animal research. Therefore, if a procedure is modified in a way that heightens pain, it necessitates a review to assess the justification for that change and determine if appropriate measures can be taken to mitigate the increased suffering. This oversight is essential in maintaining the integrity of animal research and upholding ethical standards in scientific study.

Additionally, the IACUC's mandate includes ensuring that research complies with federal regulations and institutional policies. Any procedure changes, especially those affecting pain levels, require thorough evaluation and approval to ensure that the rights of the animals are protected throughout the research process.